Globalization raises an array of moral issues. The legacy of Catholic social teaching offers “ethical coordinates” that may prove useful in guiding globalization in a manner that advances the human good. At the same time the new social context being shaped by globalization demands that the tradition of Catholic social teaching undergo development in order to adequately address the changing global reality. The article highlights both some of the resources within Catholic social teaching and some of the challenges presented to the tradition when assessing globalization.