Dignitas Infinita highlights “the indispensable nature of the dignity of the human person in Christian anthropology” and warns of “ambivalent ways in which the concept is understood today.” Among those “ambivalent ways” are plural definitions of human dignity in official Catholic teaching. There is ambivalence in definitions of Catholic sexual human dignity and Catholic social human dignity, which lead to inconsistencies in the foundation and justification of moral doctrine. In this article, we first present Catholic definitions of social and sexual human dignity. Second, we explain Pope Francis’s anthropological nuances that provide an alternative definition of human dignity, which we label holistic human dignity. Third, we evaluate and describe the harm deriving from statements in the document and by Pope Francis, a harm that results from inconsistent definitions of human dignity in doctrinal teaching.