A methodological shift occurred in the sciences in the 20th century that has irreversible repercussions for a contemporary theology of the Holy Spirit. Newton and Einstein followed fundamentally different trajectories that provide radically dissimilar frameworks for the pneumatological endeavor. Pneumatology after Einstein is located in a different cosmological framework constituted by the notions of order, rationality, relationality, symmetry, and movement. These notions provide the immediate challenges to a contemporary understanding of the Spirit in the physical universe.