On August 24, 1968, Paul VI inaugurated the Second General Conference of the Latin American Episcopate. The work sessions were held at the Medellín Seminary between August 26 and September 6. Medellín represents the reception of Gaudium et Spes within the “People of God” ecclesiology of Lumen Gentium and is considered the only example of a continental reception of Vatican II carried out in a collegial and synodal manner. This article exposes the previous debates, the main topics, and the immediate reception.